Unique is a class of item quality in Torchlight II. Unique items are color-coded gold and have specific names and enchantments. Before being identified, these items initially appear as being "Mysterious," followed by the type of weapon or armor the unique item is, such as "Mysterious Shoulders." They are rarer and generally more powerful than enchanted (green) and rare (blue) items of the same level. Unique items may also be part of a set, just like the set (blue) items found in the game.

For lists of unique items, see individual equipment and item pages. Each type of weapon and armor includes a variety of uniques, and there are also numerous unique gems.